ABSTRACT
The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official methods. The drugs complied with the B.P (1993) requirements stated in their monographs. A high performance liquid chromatography (HPLC) method was developed for the analysis of plasma chlorpropamide concentration. Pharmacokinetic parameters of chlorpropamide were derived with Winnonlin standard noncompartment software programme. About 16%, 14% and 15% decrease in the mean maximum concentration (Cmax) of chlorpropamide was observed following oral administration of chlorpropamide with chloroquine, paracetamol and Promethazine respectively. About 44%, 11% and 30% decrease in the area under curve (AUC) of chlorpropamide was observed following concurrent administration of chlorpropamide with chloroquine, paracetamol and Promethazine respectively. The plasma clearance of chlorpropamide increased by 86% following chlorpropamide interaction with chloroquine. xii The absorption half-life (t½a) of chlorpropamide increased by 4%, 85% and 69% when concomitantly administered with chloroquine, paracetamol and Promethazine respectively. The elimination constant (Kel) of chlorpropamide was found to have increased by 100% and decreased by 31% following concomitant administration of chlorpropamide with chloroquine and paracetamol respectively. The elimination half-life (t½el) of chlorpropamide was found to have decreased by 47% and increased by 13% and 29% following concomitant administration to chlorpropamide with chloroquine, paracetamol and Promethazine respectively. The study implied impaired absorption and elimination of chlorpropamide by chloroquine, paracetamol and Promethazine.
ABSTRACT
The study centers on the problems militating against effective teaching and learning of Accounting education in...
Abstract
This research work is deliberately effort by the researcher to criti...
ABSTRACT
THE IMPACT OF CUSTOMER NEEDS ASSESSMENT ON BUSINESS PERFORMANCE
This study aimed to determine the impact of customer n...
Background of the Study
Work-related stress is a pervasive issue in healthcare settings, affecting the physical and mental well-being of...
ABSTRACT
The Child’s Rights Act 2003 (CRA) is a product of International and Regional legal frameworks on the rights of the child a...
Background to the Study
Civil Society Organizations (CSOs) are enormously important players in international development...
Background of the Study
In the field of materials management, it is a well-known truth that the continuation of producti...
Background of the Study
The rapid advancement of digital technologies has revolutionized education, with instructiona...
ABSTRACT: Strategies for Promoting Industry-Relevant Certifications in Vocational Programs are crucial for enhancing student employability and...
ABSTRACT
Information and Communication Technology (ICT) has brought unprecedented changes and transformation to academic...