THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official methods. The drugs complied with the B.P (1993) requirements stated in their monographs. A high performance liquid chromatography (HPLC) method was developed for the analysis of plasma chlorpropamide concentration. Pharmacokinetic parameters of chlorpropamide were derived with Winnonlin standard noncompartment software programme. About 16%, 14% and 15% decrease in the mean maximum concentration (Cmax) of chlorpropamide was observed following oral administration of chlorpropamide with chloroquine, paracetamol and Promethazine respectively. About 44%, 11% and 30% decrease in the area under curve (AUC) of chlorpropamide was observed following concurrent administration of chlorpropamide with chloroquine, paracetamol and Promethazine respectively. The plasma clearance of chlorpropamide increased by 86% following chlorpropamide interaction with chloroquine. xii The absorption half-life (t½a) of chlorpropamide increased by 4%, 85% and 69% when concomitantly administered with chloroquine, paracetamol and Promethazine respectively. The elimination constant (Kel) of chlorpropamide was found to have increased by 100% and decreased by 31% following concomitant administration of chlorpropamide with chloroquine and paracetamol respectively. The elimination half-life (t½el) of chlorpropamide was found to have decreased by 47% and increased by 13% and 29% following concomitant administration to chlorpropamide with chloroquine, paracetamol and Promethazine respectively. The study implied impaired absorption and elimination of chlorpropamide by chloroquine, paracetamol and Promethazine.
Related Project Materials
PROBLEMS OF MARKETING GUIDANCE AND COUNSELING SERVICES IN SECONDARY SCHOOLS
ABSTRACT
Guidance and counseling is an integral part of an ideal educational system. The New En...
ASSESSMENT OF THE TOURISM POTENTIALS OF GURARA AND MAYANKA WATERFALLS IN NIGER STATE, NIGERIA
ABSTRACT
Niger State has been blessed with various tourist attraction sites and of which Gurara and Mayanka waterfalls are among. So it&r...
EFFECT OF AUDIT REPORT ON ANNUAL FINANCIAL REPORTING QUALITY OF ORGANIZATION
ABSTRACT
External auditors conduct an independent examination of a firm‟s financial statements, records...
OBESITY AND IT IMPLICATIONS AMONG RURAL ADULT
BACKGROUND OF THE STUDY
In affluent societies, obesity is the most common nutritional disorder. Obesity...
ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF NOSOCOMIAL URINARY TRACT PATHOGENS IN SURGICAL PATIENTS OF AHMADU BELLO UNIVERSITY TEACHING HOSPIAL, SHIKA-ZARIA, NIGERIA
ABSTRACT
Urinary tract infections is one of the common infectious diseases diagnosed both in community and hospital settings. Due to risi...
THE IMPLICATION AND BENEFIT OF THE USE OF SOFTWARES IN BUILDING PROJECT (CASE STUDY OF SELECTED CONSTRUCTION FIRMS AND PROJECT MANAGING FIRMS)
Abstract
Software is any set of machine-readable instruction that directs a computer processor to perfo...
EXAMINATION PRISON ADMINISTRATION AND CRIME PREVENTION IN NIGERIA
ABSTRACT
The study examined prison administration and crime prevention in Nigeria using Nigerian Prison Service, Agodi G...
TIME SERIES ANALYSIS ON THE RATE OF TYPHOID FEVER CASES IN ABIA STATE FROM 2001-2010
ABSTRACT
This research work is concerned with the time series analysis on the rate of typhoid fever cases in Abia state...
INFLUENCE OF SOCIAL MEDIA ON THE PRACTICE OF PUBLIC RELATIONS IN AN ORGANISATION
Abstract
The research which examined the Influence of Social Media on the practice of Public Relations in an Organ...
Mothers’ Breastfeeding Practices and Attitudes toward Exclusive Breastfeeding in Adamawa State, Northeastern Nigeria
ABSTRACT
Exclusive breastfeeding (EBF) practice have been a serious public health concern, not only in Nigeria but in the world at large....
